It was the third straight day of air raids on the city, Syria's commercial hub before a rebel offensive in July last year made it a key battleground in the conflict that erupted in March 2011, the Syrian Observatory for Human Rights said.
A woman was also among the dead, which killed 15 people in the Shaar district and three in Maadi, the Britain-based watchdog said.
The raids follow air strikes on rebel-held areas of Aleppo Sunday and Monday that killed 86 people, including 32 children.
The air force has been dropping barrels of explosives in a bombing campaign using both helicopters and fixed-wing aircraft, activists and the Observatory say.
A security official said the military prefers the TNT-packed barrels because they are cheaper than regular bombs, which need to be imported from Russia.
Observatory director Rami Abdel Rahman said there was a "marked escalation" in attacks, and that "this type of intensive bombing over several days demonstrates the desire of the army to advance" on rebel-held areas.
He said the focus of the bombing has been on eastern districts of Aleppo neighbouring regime-held areas. In the past two months, loyalists forces have captured numerous cities and towns to the east of Aleppo.
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